Ametantrone
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2) -mediated DNA break[1].
Product Specifications
CAS Number
[64862-96-0]
Product Name Alternative
NSC 196473; NSC 290813
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ametantrone.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C=CC=C2)C(C3=C(NCCNCCO)C=CC(NCCNCCO)=C13)=O
Molecular Formula
C22H28N4O4
Molecular Weight
412.48
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Lee CH, et al. Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles. Biochem Pharmacol. 2012;83 (9) :1208-1216.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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