Macrocalin B
Macrocalin B is a diterpenoid, which can be isolated from Isodon xerophilus. Macrocalin B inhibits the proliferation of cancer cells K562, HL-60, A549, MKN, CA and HCT with IC50 of 2.81-171 μM. Macrocalin B inhibits the telomerase in K562 with an IC50 in nanomolar level[1].
Product Specifications
CAS Number
[93781-75-0]
UNSPSC
12352005
Target
Telomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/macrocalin-b.html
Smiles
O[C@@]12[C@]34[C@]5([H])[C@]6([C@](C(C)(CCC6)C)([H])[C@@H]2O)[C@](O[C@@]3([H])[C@](C[C@@H]5O)([H])C(C4=O)=C)([H])O1
Molecular Formula
C20H26O6
Molecular Weight
362.42
References & Citations
[1]Yang Y, et al., Effects of three diterpenoids on tumour cell proliferation and telomerase activity. Nat Prod Res. 2009;23 (11) :1007-12.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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