ABT-510

ABT-510 is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD) [1][2].

Product Specifications

CAS Number

[251579-55-2]

UNSPSC

12352209

Hazard Statement

H302-H315-H319

Target

Apoptosis

Type

Peptides

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/abt-510.html

Purity

99.87

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC(N(C)CC(NCC(N[C@@H](C(C)C)C(N[C@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(NCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C46H83N13O11

Molecular Weight

994.23

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Greenaway J, et al. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol Cancer Ther. 2009 Jan;8 (1) :64-74.|[2]Punekar S, et al. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology. 2008;75 (1) :9-21. |[3]Isenberg JS, et.al. Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells. Biochem Pharmacol. 2008 Feb 15;75 (4) :875-82.