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Trimetazidine-N-oxide

Trimetazidine-N-oxide is the major active metabolite of Trimetazidine. Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM. Trimetazidine is an effective antianginal agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties.

Product Specifications

CAS Number

1644530-89-1

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trimetazidine-n-oxide.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(CN2CCN(O)CC2)C(OC)=C1OC

Molecular Formula

C14H22N2O4

Molecular Weight

282.34

References & Citations

[1]Sigmund G, et al. Doping control analysis of trimetazidine and characterization of major metabolites using mass spectrometric approaches. Drug Test Anal. 2014 Nov-Dec;6 (11-12) :1197-205.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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