Ethyl tosylcarbamate

Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877) [1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].

Product Specifications

CAS Number

[5577-13-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H332-H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ethyl-tosylcarbamate.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC)NS(=O)(C1=CC=C(C)C=C1)=O

Molecular Formula

C10H13NO4S

Molecular Weight

243.28

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27 (4) :301-27.|[2]Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57 (13), 1476–1478.|[3]Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55 (6) : p. 722-30.