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CAY10580

CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM) [1].

Product Specifications

CAS Number

64054-40-6

UNSPSC

12352005

Hazard Statement

H225, H319

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cay10580.html

Concentration

14.64 mM * 200 μL in Ethanol

Purity

97.40

Solubility

10 mM in DMSO

Smiles

O=C(O)CCCCCCN1C(CCC(O)CCCCC)CCC1=O

Molecular Formula

C19H35NO4

Molecular Weight

341.49

Precautions

H225, H319

References & Citations

[1]Billot X, et al. Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg Med Chem Lett. 2003;13 (6) :1129-1132. |[2]Olesen ET, et al. Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus. Proc Natl Acad Sci U S A. 2011;108 (31) :12949-12954. |[3]Ying F, et al. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863 (9) :1029-1040.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, 2 years

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EP

Frequently Asked Questions

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