Ezetimibe hydroxy glucuronide

Ezetimibe hydroxy glucuronide (SCH 488128) is a trace metabolite detected in dog and human plasma samples after oral administration of Ezetimibe (HY-17376) [1].

Product Specifications

CAS Number

[536709-33-8]

Product Name Alternative

SCH 488128; Ezetimibe hydroxy β-D-Glucuronide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ezetimibe-hydroxy-glucuronide.html

Solubility

10 mM in DMSO

Smiles

O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1O[C@H](C2=CC=C(F)C=C2)CC[C@@H]3[C@@H](C4=CC=C(O)C=C4)N(C5=CC=C(F)C=C5)C3=O

Molecular Formula

C30H29F2NO9

Molecular Weight

585.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Anima Ghosal, et al. Identification of human UDP-glucuronosyltransferase enzyme (s) responsible for the glucuronidation of ezetimibe (Zetia) . Drug Metab Dispos. 2004 Mar;32 (3) :314-20.|[2]Ghosal A, et al. Identification of human UDP-glucuronosyltransferase enzyme (s) responsible for the glucuronidation of ezetimibe (Zetia) . Drug Metab Dispos. 2004 Mar;32 (3) :314-20.