DC10SMe
Product Specifications
UNSPSC Description
DC10SMe is a DNA alkylator, can be used in the synthesis of antibody-drug conjugate (ADC). DC10SMe exhibits IC50s of 15 pM, 12 pM, and 12 pM for Ramos, Namalwa, and HL60/s cancer cells, respectively[1].
Target Antigen
ADC Cytotoxin; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dc10sme.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(C=CC(NC(CCSSC)=O)=C2)N1)NC3=CC4=C(C=C3)NC(C(N5C(C67[C@H](C7)C5)=CC(C8=C6C=CC=C8)=O)=O)=C4
Molecular Weight
647.77
References & Citations
[1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135122/DC10SMe-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135122/
Clinical Information
No Development Reported
CAS Number
2649727-40-0
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