Rupatadine-d4 (fumarate)
Product Specifications
UNSPSC Description
Rupatadine-d4 (fumarate) is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 μM(rabbit platelet membranes/guinea pig cerebellum membranes)[1][2][3].
Target Antigen
Autophagy; Histamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling;Others
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
CC1=CN=CC(CN2C([2H])([2H])C/C(CC2([2H])[2H])=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1.OC(/C=C/C(O)=O)=O
Molecular Weight
536.05
References & Citations
[1]Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21.|[2]Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60.|[3]Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
1795153-63-7
Curated Selection
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