Rupatadine-d4 (fumarate)

Rupatadine-d4 fumarate is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki values of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes) [1][2][3].

Product Specifications

CAS Number

[1795153-63-7]

Product Name Alternative

UR-12592 D4 (fumarate)

UNSPSC

12352005

Target

Autophagy; Histamine Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

CC1=CN=CC(CN2C([2H])([2H])C/C(CC2([2H])[2H])=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1.OC(/C=C/C(O)=O)=O

Molecular Formula

C30H26D4ClN3O4

Molecular Weight

536.05

References & Citations

[1]Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF) . J Pharmacol Exp Ther. 1997 Jan;280 (1) :114-21.|[2]Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49 (7) :355-60.|[3]Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8 (7) :e68631.