4-Desmethoxy Omeprazole

4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].

Product Specifications

CAS Number

[110374-16-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H402, H411

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4-desmethoxy-omeprazole.html

Purity

98.99

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

COC1=CC=C2N=C(S(CC3=NC=C(C)C=C3C)=O)NC2=C1

Molecular Formula

C16H17N3O2S

Molecular Weight

315.39

Precautions

H302, H315, H402, H411

References & Citations

[1]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32 (8) :821-7.|[2]Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37 (1) :145-50.