3-Iodothyronamine (hydrochloride)

3-Iodothyronamine (hydrochloride) is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure[1].

Product Specifications

CAS Number

[788824-64-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H372, H410

Target

Trace Amine-associated Receptor (TAAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-iodothyronamine-hydrochloride.html

Purity

99.5

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC1=CC=C(OC2=CC=C(CCN)C=C2I)C=C1.Cl

Molecular Formula

C14H15ClINO2

Molecular Weight

391.63

Precautions

H302, H315, H319, H335, H372, H410

References & Citations

[1]Hart ME, et al. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J Med Chem. 2006 Feb 9;49 (3) :1101-12.