Biliverdin

Biliverdin, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin can mediate the protective effects of HO-1 in many disease models including IRI and organ transplantation. Biliverdin exhibits anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant properties[1][2][3].

Product Specifications

CAS Number

[114-25-0]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/biliverdin.html

Purity

99.0

Solubility

DMSO : 3 mg/mL (ultrasonic; warming)

Smiles

OC(CCC(C(C)=C(N1)/C=C2C(C=C)=C(C(N/2)=O)C)=C1/C=C3C(CCC(O)=O)=C(C(/C=C4C(C)=C(C(N/4)=O)C=C)=N/3)C)=O

Molecular Formula

C33H34N4O6

Molecular Weight

582.65

Precautions

H315, H319

References & Citations

[1]McDonnell MC, et al. Biochemistry, Biliverdin. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing; 2025 Jan. |[2]Jansen, T., & Daiber, A. (2012) . Direct Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase?. Frontiers in pharmacology, 3, 30.|[3]Ollinger, R., et al., (2007) . Therapeutic applications of bilirubin and biliverdin in transplantation. Antioxidants & redox signaling, 9 (12), 2175–2185.