N-Acetyl-2-carboxybenzenesulfonamide

N-Acetyl-2-carboxybenzenesulfonamide is an orally active COX-1 and COX-2 inhibitor with IC50s of 0.06 μM and 0.25 μM, respectively. N-Acetyl-2-carboxybenzenesulfonamide shows anti-inflammatory activity[1].

Product Specifications

CAS Number

[849067-18-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-acetyl-2-carboxybenzenesulfonamide.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=CC=C1S(=O)(NC(C)=O)=O

Molecular Formula

C9H9NO5S

Molecular Weight

243.24

Precautions

H315, H319, H335

References & Citations

[1]Chen QH, et al. Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorg Med Chem. 2005 Apr 1;13 (7) :2459-68.|[2]Chen QH, et al. Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorg Med Chem. 2005 Apr 1;13 (7) :2459-68.