(E) -C-HDMAPP (ammonium)

(E) -C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E) -HDMAPP. (E) -C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release) [1][2].

Product Specifications

CAS Number

[933030-60-5]

UNSPSC

12352211

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/e-c-hdmapp-ammonium.html

Solubility

10 mM in DMSO

Smiles

OC/C(C)=C/CCP(OP(O)(O)=O)(O)=O.N.N.N

Molecular Formula

C6H23N3O7P2

Molecular Weight

311.21

References & Citations

[1]Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E) -1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51 (6) :1747-54.