(E) -C-HDMAPP (ammonium)
(E) -C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E) -HDMAPP. (E) -C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release) [1][2].
Product Specifications
CAS Number
933030-60-5
UNSPSC
12352211
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/e-c-hdmapp-ammonium.html
Solubility
10 mM in DMSO
Smiles
OC/C(C)=C/CCP(OP(O)(O)=O)(O)=O.N.N.N
Molecular Formula
C6H23N3O7P2
Molecular Weight
311.21
References & Citations
[1]Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E) -1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51 (6) :1747-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNFRSF1A/CD120a
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