Pyridinium bisretinoid A2E

Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE) . Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases[1][2].

Product Specifications

CAS Number

[173449-96-2]

Product Name Alternative

A2E

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Autophagy; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pyridinium-bisretinoid-a2e.html

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

OCC[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C

Molecular Formula

C42H58NO

Molecular Weight

592.92

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jeong SY, et al. Photoactivation of N-retinylidene-N-retinylethanolamine compromises autophagy in retinal pigmented epithelial cells. Food Chem Toxicol. 2019 Sep;131:110555. |[2]S. Ben-Shabat, et al; Elucidating the Role of Pyridinium bis-Retinoid (A2E) in Retinal Pigment Epithelium (RPE) Cell Damages. Invest. Ophthalmol. Vis. Sci. 2007;48 (13) :2201. |[3]Sokolov VS, et al. Interaction of pyridinium bis-retinoid (A2E) with bilayer lipid membranes. J Photochem Photobiol B. 2007 Feb 1;86 (2) :177-85.