CPI-1328
CPI-1328 is an EZH2 inhibitor with a Ki value of 63 fM.
Product Specifications
CAS Number
[2390367-27-6]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cpi-1328.html
Solubility
10 mM in DMSO
Smiles
ClC1=C2C(O[C@](O2)([C@]3([H])CC[C@H](CC3)N(C)C)C)=C(C4=C1CCN(C4=O)CC5=C(C=C(NC5=O)C)SC)C
Molecular Formula
C28H36ClN3O4S
Molecular Weight
546.12
References & Citations
[1]Stuckey JI, et al. Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity. J Biol Chem. 2021 Jan-Jun;296:100349.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2
Curated Selection
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