DBCO-PEG3-amine

DBCO-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG3-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[2093409-57-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-peg3-amine.html

Purity

99.99

Solubility

10 mM in DMSO

Smiles

NCCOCCOCCOCCNC(CCC(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)=O)=O

Molecular Formula

C27H33N3O5

Molecular Weight

479.57

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562