PF-5274857 (hydrochloride)
PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway[1].
Product Specifications
CAS Number
1613439-62-5
UNSPSC
12352005
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-5274857-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O.Cl
Molecular Formula
C20H26Cl2N4O3S
Molecular Weight
473.42
References & Citations
[1]Rohner A, et, al. Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier. Mol Cancer Ther. 2012 Jan;11 (1) :57-65.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Apolipoprotein L 1 (APOL1) Mouse Monoclonal Antibody [Clone ID: 1D4]](https://cdn.genprice.uk/products/937/68dd189a061270361e8fbd55/imageurl/am06309su-n.webp)
AM06309SU-N 100 µL
Apolipoprotein L 1 (APOL1) Mouse Monoclonal Antibody [Clone ID: 1D4]
Sign In for Pricing
View Details 
TP314155M 100 µg
CCBL2 (KYAT3) (NM_001008661) Human Recombinant Protein
Sign In for Pricing
View Details