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IDO1-IN-7

IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC50 of 6.1 nM in in the cellular assay (SKOV3) . IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2351199-98-7]

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ido1-in-7.html

Solubility

10 mM in DMSO

Smiles

FC1=CC2=C(C=C1)N=CC=C2[C@@H](CC3)[C@@H](O)CN3C(C(NC4=CC=C(Cl)C=C4)=O)=O

Molecular Formula

C22H19ClFN3O3

Molecular Weight

427.86

References & Citations

[1]Christoph Steeneck, et al. Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors. Bioorg Med Chem Lett. 2020 Dec 15;33:127744.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-134583/IDO1-IN-7-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-134583/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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