Ac-VDVAD-CHO

Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50: 46 and 15 nM) [1].

Product Specifications

CAS Number

[194022-51-0]

UNSPSC

12352209

Target

Caspase

Type

Peptides

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ac-vdvad-cho.html

Solubility

10 mM in DMSO

Smiles

CC(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@H](C=O)CC(O)=O)=O)=O)=O)=O)=O

Molecular Formula

C23H37N5O10

Molecular Weight

543.57

References & Citations

[1]Maillard MC, et al. Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Bioorg Med Chem. 2011 Oct 1;19 (19) :5833-51.