Ac-VDVAD-CHO
Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50: 46 and 15 nM) [1].
Product Specifications
CAS Number
[194022-51-0]
UNSPSC
12352209
Target
Caspase
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ac-vdvad-cho.html
Solubility
10 mM in DMSO
Smiles
CC(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@H](C=O)CC(O)=O)=O)=O)=O)=O)=O
Molecular Formula
C23H37N5O10
Molecular Weight
543.57
References & Citations
[1]Maillard MC, et al. Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Bioorg Med Chem. 2011 Oct 1;19 (19) :5833-51.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Caspase 2; Caspase 3
Curated Selection
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