PF-06371900
PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor[1].
Product Specifications
CAS Number
1622291-81-9
UNSPSC
12352005
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-06371900.html
Solubility
10 mM in DMSO
Smiles
CN1N=CC(C2=NN=C3C=CC(SC4=CC(OC)=CC=C4OC)=NN32)=C1
Molecular Formula
C17H16N6O2S
Molecular Weight
368.41
References & Citations
[1]Henderson JL, et al. Discovery and preclinical profiling of 3-[4- (morpholin-4-yl) -7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58 (1) :419-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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