PCSK9-IN-1
PCSK9-IN-1 is a novel and highly potent cyclic peptide PCSK9 inhibitor with a Ki value of 1.46 nM.
Product Specifications
CAS Number
2730022-10-1
UNSPSC
12352005
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pcsk9-in-1.html
Solubility
10 mM in DMSO
Smiles
O[C@H](C)[C@@H](C(N[C@@H](CC1=CC=C(OC)C=C1)C(N2[C@@](C(NCCSC3)=O)(C)CCC2)=O)=O)NC([C@H]4NC([C@H](CC5=CNC6=C5C=C(F)C=C6)NC([C@H](CC7=CC(CNC(CC4)=O)=CC=C7)NC([C@@H](C)NC([C@H](C)NC(CCSCC8=CC=CC3=C8)=O)=O)=O)=O)=O)=O
Molecular Formula
C65H80FN11O12S2
Molecular Weight
1290.53
References & Citations
[1]Alleyne C, et al. Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J Med Chem. 2020 Nov 25;63 (22) :13796-13824.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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