PI3Kδ-IN-8
PI3Kδ-IN-8 is a potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 3.3 nM. PI3Kδ-IN-8 shows selectivity for PI3Kδ over PI3Kα, PI3Kβ, and PI3Kγ (IC50=377.2, 241.6, 17.9 nM, respectively) . PI3Kδ-IN-8 has anti-tumor activity[1].
Product Specifications
CAS Number
2101518-75-4
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kδ-in-8.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(N[C@H](C(C(C2=CC=C(F)C=C2)=C3C=CC(F)=CN43)=C(C5=CC=CC=C5)C4=O)C)N=C(N)N=C1N
Molecular Formula
C28H21F2N7O
Molecular Weight
509.51
References & Citations
[1]Shukla MR, et, al. Discovery of a Potent and Selective PI3Kδ Inhibitor (S) -2,4-Diamino-6- ((1- (7-fluoro-1- (4-fluorophenyl) -4-oxo-3-phenyl-4H-quinolizin-2-yl) ethyl) amino) pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models. J. Med. Chem. 2020 Dec 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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