PF-429242
PF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1].
Product Specifications
CAS Number
947303-87-9
UNSPSC
12352005
Hazard Statement
H315-H319-H335-H410
Target
Fatty Acid Synthase (FASN) ; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pf-429242.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CCC1=CC=CC=C1OC)[C@H]2CNCC2)C3=CC=C(CN(CC)CC)C=C3
Molecular Formula
C25H35N3O2
Molecular Weight
409.56
Precautions
P261-P264-P271-P273-P280-P302+P352-P304+P340-P362+P364-P391-P405-P501
References & Citations
[1]Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther. 2008 Sep;326 (3) :801-8.|[2]Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8 (2) . pii: E46.|[3]Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85 (2) :795-803.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
J Neurosci Res. 2025 Jun;103 (6) :e70054.|Autophagy. 2021 Jul;17 (7) :1592-1613.|Cell Death Differ. 2021 Jun;28 (6) :2001-2018.|Cell Death Dis. 2025 Jul 11;16 (1) :512.|Hypertension. 2021 Feb;77 (2) :405-416.|Immunity. 2018 Nov 20;49 (5) :842-856.e7. |JCI Insight. 2019 Apr 4;4 (7) . pii: 124174. |Nature. 2023 Apr;616 (7956) :348-356.|Sci China Life Sci. 2022 Feb;65 (2) :341-361.
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