Z-Pro-prolinal
Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP[1][2][3].
Product Specifications
CAS Number
88795-32-8
Product Name Alternative
N-Benzyloxycarbonyl-L-prolyl-L-prolinal
UNSPSC
12352005
Hazard Statement
H302, H319
Target
Prolyl Endopeptidase (PREP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/z-pro-prolinal.html
Solubility
10 mM in DMSO
Smiles
O=C[C@H]1N(C([C@H]2N(C(OCC3=CC=CC=C3)=O)CCC2)=O)CCC1
Molecular Formula
C18H22N2O4
Molecular Weight
330.38
Precautions
H302, H319
References & Citations
[1]Tsuru D, et al. Thiazolidine derivatives as potent inhibitors specific for prolyl endopeptidase. J Biochem. 1988;104 (4) :580-586. |[2]Kilpeläinen TP, et al. The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy. Biomed Pharmacother. 2020;128:110253. |[3]Miura N, et al. Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats. Neurosci Lett. 1995;196 (1-2) :128-130.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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