Z-Pro-prolinal

Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP[1][2][3].

Product Specifications

CAS Number

[88795-32-8]

Product Name Alternative

N-Benzyloxycarbonyl-L-prolyl-L-prolinal

UNSPSC

12352005

Hazard Statement

H302, H319

Target

Prolyl Endopeptidase (PREP)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/z-pro-prolinal.html

Solubility

10 mM in DMSO

Smiles

O=C[C@H]1N(C([C@H]2N(C(OCC3=CC=CC=C3)=O)CCC2)=O)CCC1

Molecular Formula

C18H22N2O4

Molecular Weight

330.38

Precautions

H302, H319

References & Citations

[1]Tsuru D, et al. Thiazolidine derivatives as potent inhibitors specific for prolyl endopeptidase. J Biochem. 1988;104 (4) :580-586. |[2]Kilpeläinen TP, et al. The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy. Biomed Pharmacother. 2020;128:110253. |[3]Miura N, et al. Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats. Neurosci Lett. 1995;196 (1-2) :128-130.