PNP-ADPr
PNP-ADPr is a colorimetric substrate that used for the first continuous Poly (ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr can be used for the research of poly (ADP-ribose) polymerase (PARP) enzymes[1][2].
Product Specifications
CAS Number
939028-75-8
Product Name Alternative
ADP-ribose-pNP
UNSPSC
12352005
Target
Poly (ADP-ribose) Glycohydrolase (PARG)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pnp-adpr.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](OC5=CC=C([N+]([O-])=O)C=C5)O4)(O)=O)(O)=O
Molecular Formula
C21H26N6O16P2
Molecular Weight
680.41
References & Citations
[1]Drown BS, et al. Monitoring Poly (ADP-ribosyl) glycohydrolase Activity with a Continuous Fluorescent Substrate. Cell Chem Biol. 2018;25 (12) :1562-1570.e19.|[2]Nottbohm AC, et al. A colorimetric substrate for poly (ADP-ribose) polymerase-1, VPARP, and tankyrase-1. Angew Chem Int Ed Engl. 2007;46 (12) :2066-2069.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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