8-Nitroguanosine

8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].

Product Specifications

CAS Number

[337536-53-5]

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/8-nitroguanosine.html

Purity

95.52

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](N(C([N+]([O-])=O)=N2)C3=C2C(NC(N)=N3)=O)O[C@@H]1CO

Molecular Formula

C10H12N6O7

Molecular Weight

328.24

References & Citations

[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100 (11) :6646-51.