NSC 288387
NSC 288387 is a pan-flavivirus MTase inhibitor. NSC 288387 binds to the SAM-binding pocket. NSC 288387 inhibits ZIKV with an IC50 of 0.2 μM. NSC 288387 also inhibits viral replication in cell culture[1].
Product Specifications
CAS Number
[61369-43-5]
UNSPSC
12352005
Target
Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nsc-288387.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2=CC=CC=C2)N=C3N(CCOC)C4=CC=CC=C4N=C3C1=O
Molecular Formula
C19H16N4O3
Molecular Weight
348.36
References & Citations
[1]Samrat SK, et al. Broad-Spectrum Small-Molecule Inhibitors Targeting the SAM-Binding Site of Flavivirus NS5 Methyltransferase. ACS Infect Dis. 2023 Jul 14;9 (7) :1319-1333.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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