N-Acetylserine

N-Acetylserine (N-Acetyl-L-serine) is a physiological inducer of cysteine biosynthesis and activator of CysB. N-Acetylserine can bind to the CysB apoprotein. N-Acetylserine stimulates cysJIH transcription in vitro. N-Acetylserine can be used in the research of SARS-CoV-2 infection[1][2][3][4].

Product Specifications

CAS Number

[16354-58-8]

Product Name Alternative

N-Acetyl-L-serine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/n-acetylserine.html

Purity

98.0

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

OC[C@@H](C(O)=O)NC(C)=O

Molecular Formula

C5H9NO4

Molecular Weight

147.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Lynch AS, et al. Characterization of the CysB protein of Klebsiella aerogenes: direct evidence that N-acetylserine rather than O-acetylserine serves as the inducer of the cysteine regulon. Biochem J. 1994 Apr 1;299 (Pt 1) (Pt 1) :129-36.|[2]Ostrowski J, et al. Molecular characterization of the cysJIH promoters of Salmonella typhimurium and Escherichia coli: regulation by cysB protein and N-acetyl-L-serine. J Bacteriol. 1989 Jan;171 (1) :130-40.|[3]Gama-Almeida MC, et al. Integrated NMR and MS Analysis of the Plasma Metabolome Reveals Major Changes in One-Carbon, Lipid, and Amino Acid Metabolism in Severe and Fatal Cases of COVID-19. Metabolites. 2023 Jul 24;13 (7) :879. |[4]Franke I, et al. YfiK from Escherichia coli promotes export of O-acetylserine and cysteine. J Bacteriol. 2003 Feb;185 (4) :1161-6.