AICAR-13C2,15N
AICAR-13C2,15N (Acadesine-13C2,15N; AICA Riboside-13C2,15N) is the 13C and 15N labeled AICAR (HY-13417) [1]. AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor[2][3].
Product Specifications
CAS Number
[1609374-70-0]
Product Name Alternative
Acadesine-13C2,15N; AICA Riboside-13C2,15N
UNSPSC
12352005
Target
AMPK; Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; Mitophagy; YAP
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/aicar-13c2-15n.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2[13C](N)=[13C]([15N]=C2)C(N)=O)O1
Molecular Formula
C7 13C2H14N3 15NO5
Molecular Weight
261.21
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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