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AICAR-13C2,15N

AICAR-13C2,15N (Acadesine-13C2,15N; AICA Riboside-13C2,15N) is the 13C and 15N labeled AICAR (HY-13417) [1]. AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor[2][3].

Product Specifications

CAS Number

[1609374-70-0]

Product Name Alternative

Acadesine-13C2,15N; AICA Riboside-13C2,15N

UNSPSC

12352005

Target

AMPK; Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; Mitophagy; YAP

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/aicar-13c2-15n.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2[13C](N)=[13C]([15N]=C2)C(N)=O)O1

Molecular Formula

C7 13C2H14N3 15NO5

Molecular Weight

261.21

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Curated Selection

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