Cariporide (mesilate)
Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1[1].
Product Specifications
CAS Number
159138-81-5
Product Name Alternative
HOE-642
UNSPSC
12352005
Hazard Statement
H317
Target
Potassium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cariporide-mesilate.html
Solubility
10 mM in DMSO
Smiles
O=C(NC(N)=N)C1=CC=C(C(C)C)C(S(=O)(C)=O)=C1.CS(=O)(O)=O
Molecular Formula
C13H21N3O6S2
Molecular Weight
379.45
Precautions
P261-P272-P280-P302+P352-P362+P364-P501
References & Citations
[1]Wang SX, et al. Cariporide inhibits high glucose-mediated adhesion of monocyte-endothelial cell and expression of intercellular adhesion molecule-1. Life Sci. 2006 Aug 29;79 (14) :1399-404.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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