Tauro-α-muricholic acid (sodium)

Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM) . Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal[1][2].

Product Specifications

CAS Number

[2260905-08-4]

Product Name Alternative

T-α-MCA (sodium)

UNSPSC

12352211

Target

Endogenous Metabolite; FXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tauro-α-muricholic-acid-sodium.html

Purity

99.9

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)[C@@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C26H44NNaO7S

Molecular Weight

537.68

References & Citations

[1]Chen W, et al. Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect. Int J Med Sci. 2023 Apr 2;20 (5) :595-605.|[2]Ye X, et al. Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism. Eur J Pharmacol. 2021 Oct 5;908:174341.