Cyclobenzaprine N-oxide

Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine (HY-B0740) in liver particles. Cyclobenzaprine is a skeletal muscle relaxant and is active on the central nervous system. The liver cytosol from liver particles has reductase activity that can reduce Cyclobenzaprine N-oxide to the corresponding amine[1][2][3].

Product Specifications

CAS Number

[6682-26-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cyclobenzaprine-n-oxide.html

Solubility

10 mM in DMSO

Smiles

C[N+](C)([O-])CC/C=C1C2=CC=CC=C2C=CC3=CC=CC=C\13

Molecular Formula

C20H21NO

Molecular Weight

291.39

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Kitamura S, et al. Reduction of tertiary amine N-oxides by liver preparations: function of aldehyde oxidase as a major N-oxide reductase. Biochem Biophys Res Commun. 1984 Jun 29;121 (3) :749-54.|[2]Kobayashi, et al. Ono, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol, 1996. 311 (1) : p. 29-35.|[3]Belvedere G, et al. Identification of cyclobenzaprine-10, 11-epoxide and other metabolites after incubation of cyclobenzaprine with rat liver microsomes[J]. Xenobiotica, 1975, 5 (12) : 765-771.