Venetoclax N-oxide
Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM[1].
Product Specifications
CAS Number
[2469279-00-1]
UNSPSC
12352005
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/venetoclax-n-oxide.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CC[N+](CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)([O-])CC4)C=C3OC7=CN=C(NC=C8)C8=C7
Molecular Formula
C45H50ClN7O8S
Molecular Weight
884.44
References & Citations
[1]Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19 (2) :202-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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