Venetoclax N-oxide

Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM[1].

Product Specifications

CAS Number

[2469279-00-1]

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/venetoclax-n-oxide.html

Solubility

10 mM in DMSO

Smiles

O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CC[N+](CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)([O-])CC4)C=C3OC7=CN=C(NC=C8)C8=C7

Molecular Formula

C45H50ClN7O8S

Molecular Weight

884.44

References & Citations

[1]Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19 (2) :202-8.