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Alaproclate (hydrochloride)

Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI) . Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow[1][2].

Product Specifications

CAS Number

60719-83-7

Product Name Alternative

GEA 654 (hydrochloride) ; A03 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor; iGluR; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/alaproclate-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

NC(C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O.[H]Cl

Molecular Formula

C13H19Cl2NO2

Molecular Weight

292.20

Precautions

H302

References & Citations

[1]Campagna J, et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 Dec 4;8 (1) :17574.|[2]Wilkinson A, et al. Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature, keep dry and cool

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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