Alaproclate (hydrochloride)

Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI) . Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow[1][2].

Product Specifications

CAS Number

[60719-83-7]

Product Name Alternative

GEA 654 (hydrochloride) ; A03 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor; iGluR; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/alaproclate-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

NC(C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O.[H]Cl

Molecular Formula

C13H19Cl2NO2

Molecular Weight

292.20

Precautions

H302

References & Citations

[1]Campagna J, et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 Dec 4;8 (1) :17574.|[2]Wilkinson A, et al. Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.