Heliotrine N-oxide

Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128) . Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo[1].

Product Specifications

CAS Number

[6209-65-0]

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/heliotrine-n-oxide.html

Solubility

10 mM in DMSO

Smiles

[O-][N+]1(CC[C@@H]2O)[C@]2([H])C(COC([C@@](C(C)C)(O)[C@@H](C)OC)=O)=CC1

Molecular Formula

C16H27NO6

Molecular Weight

329.39

Precautions

P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]Xiaobo He, et al. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25 (4) :984-991.