Propargyl-O-C1-amido-PEG3-C2-NHS ester
Propargyl-O-C1-amido-PEG3-C2-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Propargyl-O-C1-amido-PEG3-C2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
2101206-78-2
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/propargyl-o-c1-amido-peg3-c2-nhs-ester.html
Solubility
10 mM in DMSO
Smiles
C#CCOCC(NCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O
Molecular Formula
C18H26N2O9
Molecular Weight
414.41
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Cytokeratin, HMW (AE-3), CF647 conjugate, 0.1mg/mL
SOX2 (Transcription Factor) (SOX2/1792), CF488A conjugate, 0.1mg/mL
CD6 (Negative Marker of T-regulatory Cells) (C6/2884R), CF647 conjugate, 0.1mg/mL
