HyNic-PEG2-TCO
HyNic-PEG2-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. HyNic-PEG2-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Product Specifications
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hynic-peg2-tco.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=N/NC(C=C1)=NC=C1C(NCCOCCOCCNC(OC2CCC/C=C/CC2)=O)=O
Molecular Formula
C24H37N5O5
Molecular Weight
475.58
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
Frequently Asked Questions
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