HyNic-PEG2-TCO

HyNic-PEG2-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. HyNic-PEG2-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hynic-peg2-tco.html

Solubility

10 mM in DMSO

Smiles

C/C(C)=N/NC(C=C1)=NC=C1C(NCCOCCOCCNC(OC2CCC/C=C/CC2)=O)=O

Molecular Formula

C24H37N5O5

Molecular Weight

475.58

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562