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(S, R, S) -AHPC-C8-NH2 (hydrochloride)

(S, R, S) -AHPC-C8-NH2 (VH032-C8-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

2376139-49-8

Product Name Alternative

VH032-C8-NH2 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-c8-nh2-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCCCN)=O

Molecular Formula

C31H48ClN5O4S

Molecular Weight

622.26

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jian Jin, et al. Serine threonine kinase (akt) degradation / disruption compounds and methods of use. Patent WO2019173516A1.|[2]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[3]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Von Hippel-Lindau (VHL)

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