TCO-PEG11-TCO
Product Specifications
UNSPSC Description
TCO-PEG11-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG11-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-peg11-tco.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@H]1CCC/C([H])=C/CC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(O[C@H]2CCC/C([H])=C/CC2)=O
Molecular Weight
849.06
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-133478/TCO-PEG11-TCO-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-133478/
Clinical Information
No Development Reported
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