TCO-PEG11-TCO

TCO-PEG11-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG11-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg11-tco.html

Solubility

10 mM in DMSO

Smiles

O=C(O[C@H]1CCC/C([H])=C/CC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(O[C@H]2CCC/C([H])=C/CC2)=O

Molecular Formula

C42H76N2O15

Molecular Weight

849.06

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562