(S)-TCO-PEG3-maleimide
Product Specifications
UNSPSC Description
(S)-TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. (S)-TCO-PEG3-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-tco-peg3-maleimide.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@H]1CCC/C([H])=C/CC1)NCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O
Molecular Weight
495.57
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-133477/S-TCO-PEG3-maleimide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-133477/
Clinical Information
No Development Reported
Curated Selection
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