DBCO-PEG12-Maleimide

DBCO-PEG12-Maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG12-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-nhco-peg12-maleimide.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(CCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)N2C3=CC=CC=C3C#CC4=CC=CC=C4C2

Molecular Formula

C52H74N4O17

Molecular Weight

1027.16

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562