TTBK1-IN-2
TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 µM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice[1].
Product Specifications
CAS Number
2765453-51-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ttbk1-in-2.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
ClC1=CC=C(OC2=CC=C(C=C2)NC3=C4C(NC=C4)=NC=N3)C=C1
Molecular Formula
C18H13ClN4O
Molecular Weight
336.78
Precautions
H302, H315, H319
References & Citations
[1]Nozal V, et al. TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. J Med Chem. 2022;65 (2) :1585-1607.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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