FAICAR

FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and substrate for the IMP cyclohydrolase of ATIC from Cryptococcus neoformans. FAICAR is a key intermediate in the de novo purine biosynthesis pathway. FAICAR can be used in the research of diseases associated with Cryptococcus neoformans infection[1][2].

Product Specifications

CAS Number

[13018-54-7]

Product Name Alternative

5-Formamidoimidazole-4-carboxamide ribotide

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/faicar.html

Purity

85.81

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(NC=O)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=N1)N

Molecular Formula

C10H15N4O9P

Molecular Weight

366.22

References & Citations

[1]E Szabados, et al. Radioassay of bifunctional 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase by thin-layer chromatography. Anal Biochem|[2]Wizrah MSI, et al. AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. J Biol Chem. 2022 Oct;298 (10) :102453.